Selective suppression of tumor cells by a tumor-specific bicistronic lentiviral vector
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چکیده
منابع مشابه
Stability Adenovirus through Increased p53 Protein Translation and Enhanced Tumor Suppression by a p14ARF/p53 Bicistronic
The p53 tumor suppressor controls a cell cycle arrest and apoptosis pathway that is central to tumor suppression and often disrupted in cancer. The accumulation and activity of p53 are positively controlled by the p14 ADP p14ARF ribosylation factor (AR) tumor suppressor, and full restoration of the pathway in cancer cells may require that both p53 and p14ARF be supplied. To address this issue, ...
متن کاملEnhanced tumor suppression by a p14ARF/p53 bicistronic adenovirus through increased p53 protein translation and stability.
The p53 tumor suppressor controls a cell cycle arrest and apoptosis pathway that is central to tumor suppression and often disrupted in cancer. The accumulation and activity of p53 are positively controlled by the p14/ARF tumor suppressor and full restoration of the pathway in cancer cells may require that both p53 and p14ARF be supplied [corrected]. To address this issue, we have constructed a...
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Purpose: To recognize affective factors in delivering X-ray contrast agents (which have high atomic number) via gallium carrier to liver or lymphatic neoplasm cells. Materials and Methods: Since uptake of gallium by liver has been reported in numerous researches, it was bonded with a contrast media (metrizoate). X-ray imaging was done to determine geometric features of liver. Results: Rad...
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Experiments are reported in detail which show that an antibody which appears in the blood of certain rabbits implanted with the Brown-Pearce tumor or injected with cell-free extracts of it is capable of suppressing the growth of the tumor cells under a variety of experimental conditions, the effects of the antibody being wholly distinct from those of unknown factors that frequently bring about ...
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In the CT26 BALB/c murine model of colorectal carcinoma, depletion of regulatory T cells (Tregs) prior to tumor inoculation results in protective immunity to both CT26 and other BALB/c-derived tumors of diverse histological origin. In this paper, we show that cross-protection can be conferred by adoptively transferred CD8(+) CTLs. Other schedules for inducing immunity to CT26 have been describe...
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ژورنال
عنوان ژورنال: TURKISH JOURNAL OF BIOLOGY
سال: 2016
ISSN: 1300-0152,1303-6092
DOI: 10.3906/biy-1512-53